Inflammatory responses in BUF rats.
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- Ishizuki Satoshi
- Department of Toxicology, Hokkaido Institute of Pharmaceutical Sciences
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- Kanda Naritoshi
- Department of Toxicology, Hokkaido Institute of Pharmaceutical Sciences
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- Kaneta Shigeru
- Department of Toxicology, Hokkaido Institute of Pharmaceutical Sciences
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- Fujihira Eiichi
- Department of Toxicology, Hokkaido Institute of Pharmaceutical Sciences
Bibliographic Information
- Other Title
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- Ｂｕｆｆａｌｏ系ラットにおける炎症応答
Abstract
Buffalo (BUF) rats of an adjuvant-arthritis low responder strain (a 39% incidence) responded to subcutaneously and intravenously injected dextran to a more intensive degree, as compared to F 344 rats which were highly susceptible to adjuvant arthritis (a 100% incidence) . Six days after subcutaneous implantation of coverslips, the newly formed granulation tissue was found in F 344 rats, but scarcely in BUF rats. Multinucleated giant cells, together with lymphocytes and mononuclear cells, appeared frequently on the surface of the implanted coverslips in BUF rats, while clusters of polymorphs as well as other blood and tissue cells were predominant in F 344 rats. Levamisole, cyclophosphamide and D-penicillamine enhanced significantly the incidence and severity of adjuvant disease in BUF rats only when administered daily for 3 days starting from one day before adjuvant injection or daily for 5 days from the day of injection. Administration of carbon particles, alginate and other substances failed to produce any significant enhancement of the disease onset in the adjuvant-injected animals of this strain. However, swelling in the adjuvantinjected hind foot continued to increase for a long time, and responded rapidly to administered anti-inflammatory drugs. The present communication discusses a possible important role of macrophages in the inflammatory lesions induced in BUF rats.
Journal
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- Ensho
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Ensho 5 (1), 20-28, 1985
The Japanese Society of Inflammation and Regeneration
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Details 詳細情報について
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- CRID
- 1390282679761566592
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- NII Article ID
- 130003856750
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- ISSN
- 18844006
- 03894290
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
