LDL-apheresisのリポ蛋白除去に対するリポ蛋白脂質構成の影響

• 伊藤 博夫

  帝京大学第1内科

• 石井 寿美

  帝京大学第1内科

• 街 稔

  帝京大学第1内科

• 武田 佳代子

  帝京大学第1内科

• 中村 一路

  帝京大学第1内科

• 長瀬 光昌

  帝京大学第1内科

• 川村 光信

  東京逓信病院内科

• 内藤 周幸

  東京逓信病院内科

書誌事項

タイトル別名

• Effect of the difference in lipid composition on adsorption of lipoproteins to the dextran-sulfate cellulose column
• Comparison between type IIa and type V hyperlipoproteinemia
• IIa型およびV型高リポ蛋白血症に対する検討

抄録

We investigated whether the therapeutic effect using a dextran-sulfate cellulose (DSC) column might be influenced by variations in plasma lipid composition. LDL-apheresis using the DSC column was performed in patients with type IIa homozygous familial hypercholesterolemia (FH), type IIa heterozygous FH, and type V hyperlipoproteinemia. In all patients, the removal rate of lipids was the highest for LDL. Among apolipoproteins, apolipoproteins B and E were removed selectively by DSC column in all patients. For plasma separation, hollow fibers were less effective in type V hyperlipoproteinemia than in FH.<br>After LDL-apheresis using the DSC column, the attacks of abdominal pain noted before LDL-apheresis in a patient with type V hyperlipoproteinemia were improved, and regression of tuberous and tendinous xanthoma was induced in patients with FH.<br>The data suggest that, by the use of the DSC column, a therapeutic effect can be induced independent of variations in lipid composition. Therefore, LDL-apheresis is equafy effective in patients with type IIa and type V hyperlipoproteinemia.

収録刊行物

• 日本透析療法学会雑誌

  日本透析療法学会雑誌 22 (3), 337-342, 1989

  社団法人 日本透析医学会

キーワード

• LDL-aheresis
• dextran-sulfate cellulose
• lipid composition
• familial hypercholesterolema
• type V hyperlioproteinemia

詳細情報

• CRID: 1390001204674693120
• NII論文ID: 130003874125
• DOI: 10.4009/jsdt1985.22.337
• ISSN: 18846211
• ISSN: 09115889
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可