慢性血液透析症例におけるｒｅｃｏｍｂｉｎａｎｔ　ｈｕｍａｎ　ｅｒｙｔｈｒｏｐｏｉｅｔｉｎ（ｒＥＰＯ）の赤血球機能に与える影響

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  • The effects of rEPO on erythrocyte function in patients on maintenance hemodialysis.

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We studied the influence of rEPO on erythrocyte function in patients (26 cases) on maintenance hemodialysis.<br>We recognized that anemia was ameliorated by iron supplementation in anemic patients whose anemia had been improved and stabilized by the administration of rEPO. It is assumed that the administration of rEPO may stimulate production of microcytic and hypochromic erythrocytes in the condition of iron deficiency. In terms of ferrokinetics, %rcu was increased and PIDT1/2 was shortened by administration of rEPO, therefore, the utilzation of iron was increased by administration of rEPO. The life span of the erythrocyte was not significantly changed by the administration of rEPO. But there was a significant negative corrlation between the improvement in anemia and the life span of erythrocytes, ie in proportion to the improvement in anemia the life span of erythrocytes becomes shorter. The fragility of erythrocytes did not change significantly with administration of rEPO. rEPO is the most effective agent for treatment of anemia in hemodialysis patients. It is, however, postulated that rEPO stimulates the production of abnormal erythrocytes, ie microcytic, hypochromic or immature erythrocytes, in a condition of iron deficiency.

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