書誌事項
- タイトル別名
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- Contribution of hemolysis to erythropoietin refractory anemia in patients on peritoneal dialysis.
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To investigate the contribution of hemolysis to anemia of peritoneal dialysis patients, we measured serum haptoglobin (Hp) levels in 47 patients on peritoneal dialysis.<br>The 4 patients (8.5%) whose Hp values were below the measurement sensitivity level (<10mg/dl) were assigned the hemolytic group, while another 43 patients (91.5%) were assigned to the non-hemolytic group. Serum lactate dehydrogenase and reticulocyte counts were significantly higher in the hemolytic group than in the non-hemolytic group (540.0±132.8 vs. 405.5±105.0IU/l, p<0.05 and 28.7±6.6 vs. 18.0±9.0‰, p<0.05). Hemoglobin concentration was significantly lower in the hemolytic group than in the non-hemolytic group (8.73±0.78 vs. 9.83±1.00g/dl, p<0.05). Doses of recombinant human erythropoietin tended to be higher in the hemolytic group (33000±6000 units/month vs. 20230±12490 units/month, p=0.051). However, dialysis duration, serum creatinine, β2-microglobulin, intact parathyroid hormone, weekly Kt/V and weekly Ccr were not significantly different between the two groups.<br>The results of this study suggest that hemolysis may be a frequent cause of resistance to recombinant human erythropoietin therapy in peritoneal dialysis patients with anemia.
収録刊行物
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- 日本透析医学会雑誌
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日本透析医学会雑誌 33 (6), 1029-1034, 2000
一般社団法人 日本透析医学会
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詳細情報 詳細情報について
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- CRID
- 1390001204676912128
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- NII論文ID
- 130003875025
- 10005248858
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- NII書誌ID
- AN10432053
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- ISSN
- 1883082X
- 13403451
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可