Granule Release from Endocrine Cells in Acidified Human Duodenal Bulb: An Electron Microscope Study of Biopsy Materials

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  • OSAKA Michitoshi
    Department of Anatomy, Niigata University School of Medicine Niigata City Hospital
  • SASAGAWA Tsutomu
    Department of Anatomy, Niigata University School of Medicine Niigata City Hospital
  • FUJITA Tsuneo
    Department of Anatomy, Niigata University School of Medicine Niigata City Hospital

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  • 酸によるヒトの十二指腸球部の内分泌細胞からの果粒放出
  • サン ニ ヨル ヒト ノ ジュウニシチョウキュウブ ノ ナイブンピ サイボウ カラ ノ カリュウ ホウシュツ エイブン

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Abstract

The endocrine cells of the human duodenal bulb were observed under the electron microscope in biopsy tissues taken by normal procedure and after luminal acidification.<br>1. The endocrine cells in this portion were found more frequently than in the lower part of the duodenum previously examined by our research group.<br>2. At least 9 types of endocrine cells were distinguished by their fine structures, i.e., EC, EC-like, D, D1, G, L. M, S and A-like cells.<br>3. Emiocytotic granule release was recognized in 4 types, i.e., D, D1, L and M cells, 5min after the infusion of 40ml of 0.1N HCl (pH 1.5) into the duodenal lumen.<br>4. The hormones produced by these 4 cell types were proposed to be anti-acidic agents such as secretin, enterogastrone or GIP, CCK-PZ and enteroglucagon.<br>5. The possible significance of the other 5 types of endocrine cells were also discussed.

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