Synthesis of Kifunensine, an Immunomodulating Substance Isolated from a Microbial Source.

• 茅切 浩

• 笠原 千義

• 中村 克哉

• 奥 照夫

• 橋本 眞志

抄録

Kifunensine (1), a novel immunomodulat isolated from an actinomycete, was enantiospecifically synthesized from D-mannosamine via a double cyclization of the oxamide-aldehyde precursor with ammonia as a key stop. The absolute stereochemistry of natural kifunensine was confirmed to be the D form.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 39 (6), 1392-1396, 1991

  公益社団法人 日本薬学会

キーワード

• kifunensine
• D-mannosamine
• enantiospecific synthesis
• double cyclization
• polyhydroxylated piperidine
• 4, 5-dioxoimidazolidine
• immunomodulator
• α-mannosidase inhibitor

詳細情報

• CRID: 1390001204160410496
• NII論文ID: 130003945588
• DOI: 10.1248/cpb.39.1392
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/39/6/39_6_1392/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可