Purealidins J-R, New Bromotyrosine Alkaloids from the Okinawan Marine Sponge Psammaplysilla purea.

• 小林 淳一

• 本間 かおり

• 佐々木 琢磨

• 津田 正史

抄録

Nine new bromotyrosine alkaloids, purealidins J-R (1-9), have been isolated from the Okinawan marine sponge Psammaplysilla purea and the structures were elucidated on the basis of spectroscopic data. A hydroxy group as C-1 of purealidins M-O (4-6) may be biosynthetically derived from ring-opening of a spirocyclohexadienyl-isoxazole unit of purealidin J (1), aerophobin-1 (10), and purealidin L (3), respectively. Purealidins N (5), P (7), and Q (8) were cytotoxic to tumor cell lines, while purealidins J (1), K (2), P (7), and Q (8) showed moderate inhibitory activity against epidermal growth factor (EGF) receptor kinase.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 43 (3), 403-407, 1995

  公益社団法人 日本薬学会

キーワード

• sponge
• Psammaplysilla purea
• bromotyrosine alkaloid
• purealidin
• cytotoxic
• epidermal growth factor receptor kinase

詳細情報

• CRID: 1390282679137413376
• NII論文ID: 130003946788
• DOI: 10.1248/cpb.43.403
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/43/3/43_3_403/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可