Enantio- and diastereocontrolled synthesis of epibatidine analogues.

• HIROYA Kou

• UWAI Koji

• OGASAWARA Kunio

Abstract

Three structural analogus of a potent non-opiate analgesic alkaloid epibatidine have been synthesized in optically pure forms in enantio- and diastereo-controlled ways using a chiral 2, 5-cyclohexadiene-1, 4-diol synthon.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 43 (5), 901-903, 1995

  The Pharmaceutical Society of Japan

Keywords

• epibatidine
• 7-azabicyclo[2.2.1]heptane
• epibatidine analogue
• enantiocontrolled synthesis

Details

• CRID: 1390282679137685632
• NII Article ID: 130003946834
• DOI: 10.1248/cpb.43.901
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/43/5/43_5_901/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed