Studies on Agents with Vasodilator and ,B-Blocking Activities. IV.

• SEKI Toshimi

• NAKAO Tomio

• MASUDA Takeshi

• HASUMI Kohichi

• GOTANDA Kotaro

• ISHIMORI Tsutomu

• HONMA Seijiro

• MINAMI Nobuyoshi

• SHIBATA Kenyu

• YASUDA Kikuo

抄録

A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 44 (11), 2061-2069, 1996

  公益社団法人 日本薬学会

キーワード

• phenoxypropanolamine
• pyridazinone
• hypotensive activity
• β-blocking activity
• congestive heart failure

詳細情報

• CRID: 1390282679140701184
• NII論文ID: 130003947061
• DOI: 10.1248/cpb.44.2061
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 8945771
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/44/11/44_11_2061/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可