萎縮性粘膜素因に関する研究

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  • STUDIES ON THE FACTOR PREDISPOSING TO ATROPHIC MUCOSA

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Elucidation of the relationship between air pollution and the living body presupposes investigation on the behavior of the receptor organ of the latter as well as envirmonmental factors. The author, having studied for a predisposing factor in the mucosa of the airway as the receptor organ, has been able to demonstrate the consistent presence of such a factor, even in juvenile patients. The pertinent results are presented below while the relationship between the factor and air pollution is discussed.<BR>1. Rhinobronchitis atrophicans gives rise to nasal and bronchial symptoms. Examinations will reveal atrophic lesions in nasal, tracheal and bronchial mucous membranes.<BR>Our series of 29 cases of the disease were divided according to the presence or absence of complicating sinusitis into 2 groups: one consisting of 20 cases of the primary type or without a complication of sinusitis and the other of 9 cases of the secondary type. There were 11 juvenile patients (under 20 of age) in the former group, consisting of 6 males and 5 females.<BR>2. In a series of 145 cases of atrophic rhinists, a study was made of the incidence of a complicating atrophic lesion in the mucosa of the airway, i. e., the trachea or bronchi, and the digestive tract or the esophagus and stomach. For the trachea or bronchi, such a lesion was detected in 64.5% of these cases ; for the esophagus, in 62.5%; and for the stomach, in 78.0%. In juvenile patients of the primary type or without involvement of the paranasal sinuses, the incidence was 68.8, 70.0 and 72.2% respectively. When viewed in its relation to the type of symptoms present in nasal cavity, atrophic lesion was exceedingly frequent in cases of ozena with crust formation and an offensive odor.<BR>3. Inquiry by questionnaire was made into nasal, pharyngolaryngeal, thoracic, abdominal and general symptoms as well as some other factors including nutritional status in our series of patients as divided into 3 groups according to the outstanding macroscopic feature of nasal mucosa: atrophic, hypertrophic and normal.<BR>4. The results obtained, together with other. clinical data cited earlier, affirmed the presence of apredisposing factor for atrophic mucosa in juvenile patients. This fact provides a major clue in elucidating the relationship between air pollution and the pathology of the mucosa of the airway as the receptor organ of the body. A filtrative defensive mechanism of several orders in the respiratory system has also been discussed in relation to the onset of illnesses due to air pollution.

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