前立腺癌高線量率組織内照射における線量投与法の研究　（Ｉ）―最適化プログラムについての検討―

• 隅田 伊織

  大阪犬学大学院医学系研究科生体統合医学専攻生体情報医学講座集学放射線治療学

• 吉岡 靖生

  大阪犬学大学院医学系研究科生体統合医学専攻生体情報医学講座集学放射線治療学 静岡県立静岡がんセンター放射線治療科

• 田中 英一

  大阪大学大学院医学系研究科未来医療開発専攻医用制御工学講座画像応用治療分野

• 井上 武宏

  大阪犬学大学院医学系研究科生体統合医学専攻生体情報医学講座集学放射線治療学

• 井上 俊彦

  大阪犬学大学院医学系研究科生体統合医学専攻生体情報医学講座集学放射線治療学

書誌事項

タイトル別名

• RESEARCH ON DOSE PRESCRIPTION IN HIGH DOSE RATE INTERSTITIAL BRACHYTHERAPY FOR PROSTATE CANCER (I)-FOCUSING ON OPTIMIZATION PROGRAM-
• FOCUSING ON OPTIMIZATION PROGRAM
• 最適化プログラムについての検討

抄録

In high dose rate interstitial brachytherapy for prostate cancer, we compared a Geometrical optimization method and a Dose point optimization method in terms of coverage index (CI) and dose nonuniformity ratio (DNR) computed from dose volume histograms (DVHs) of respective dose distributions, under several different conditions of dose prescription points. In the Geometrical optimization method, we set the prescribed isodose curves as those crossing the prescription points placed at 3-, 5-and 10-mm distant from the applicators, respectively. When the distance was as close as 3mm, the CI was less than 90%. With 5 and 10mm, the CIs were large enough (97% and 100%); while in the case of 10 mm, the DNR was as high as 0.84, that is, yielding a too high dose volume. In the Dose point optimization method, when the prescription points were placed on the surface of CTV, the CI was as low as 72%, indicating that the Dose point optimization method failed to prescribe the given dose on CTV surface. When the dose points were placed at the distances of 5-and 10-mm outside of CTV, the CIs were 91%, and 100%; while the DNRs were as high as 0.64 and 0.85, respectively, indicating dose volumes their were too high. Whichever “optimization” program is used, it does not always ensure a good dose distribution, and so radiation oncologists should examine the dosedistribution carefully without overestimating the“computer-optimized” one.

収録刊行物

• 日本放射線腫瘍学会誌

  日本放射線腫瘍学会誌 15 (1), 37-42, 2003

  一般社団法人 日本放射線腫瘍学会

キーワード

• Optimization
• High-dose-rate brachytherapy
• Dose prescription
• Prostate cancer

詳細情報

• CRID: 1390282679308944512
• NII論文ID: 130003997856
• NII論文ID: 10020584028
• NII書誌ID: AN10123988
• DOI: 10.11182/jastro1989.15.37
• ISSN: 18819885
• ISSN: 10409564
• Web Site: https://search.jamas.or.jp/link/ui/2003251511
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可