Osteoradionecrosis of the mandible following treatment with radium implant for tongue cancer.

• 荻野 尚

  Department of Radiology. The National Cancer Center East Hospital Department of Radiation Therapy, The National Cancer Center Hospital

• 秋元 哲夫

  Department of Radiation Therapy, The National Cancer Center Hospital

• 秋根 康之

  Department of Radiation Therapy, The National Cancer Center Hospital

• 築山 巌

  Department of Radiation Therapy, The National Cancer Center Hospital

• 柄川 順

  Department of Radiation Therapy, The National Cancer Center Hospital

抄録

One hundred and ninety-two patients with carcinoma of the mobile tongue were treated with radium implants from 1962 to 1975. Of the 128 patients who survived without local recurrence over two years, osteoradionecrosis of the mandible developed in 58 (45%). Twenty-eight of 58 patients (48%) had a mild injury (healed with or without medication), 23 (40%) had a moderate injury (treated with sequestrectomy) and 7 developed severe injury (fracture and/or required surgery). The median time of onset was 10 months after the initial treatment. The incidence in order of frequency and the degree in order of severity according to the method of implantation were volume, double-plane and single-plane implants. Frequency and severity also increased with advancing T-stage. The dose by external irradiation was correlated with the incidence of the injury. The results suggest that, for the combined treatment group with external irradiation and implantation, the time-dosefractionation factor (TDF) has a linear relation to the incidence of osteoradionecrosis at any T-stage. The TDF value is considered to be a simple and good prognosticator of the incidence of osteoradionecrosis following radiotherapy.

収録刊行物

• 日本放射線腫瘍学会誌

  日本放射線腫瘍学会誌 4 (3), 189-196, 1992

  一般社団法人 日本放射線腫瘍学会

キーワード

• Carcinoma of the mobile tongue
• Osteoradionecrosis of the mandible
• Radium implant
• Time-dose-fractionation factor

詳細情報

• CRID: 1390001204331880960
• NII論文ID: 130003997931
• DOI: 10.11182/jastro1989.4.189
• ISSN: 18819885
• ISSN: 10409564
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可