ストリキニン全身投与による成熟ラット下歯そう神経切断後の三さ神経せき髄路核尾側亜核ニューロンの越シナプス性変性

DOI

書誌事項

タイトル別名
  • Strychnine-enhanced transsynaptic neural degeneration in the trigeminal subnucleus caudalis following transection of the inferior alveolar nerve in adult rats.

抄録

Transsynaptic destruction of dendrites of second order neurons is known to take placefollowing peripheral axotomy of primary afferent neurons. This study examines the effect of systemicadministration of a convulsant strychnine on the transsynaptic effect of transection of the inferior alveolar nerve in adult rats. Following transection of the inferior alveolar nerve, 1 mg/kg/day of strychinewas administered intraperitoneally at various posttransectional intervals for 3-23 days. The experimentrevealed degeneration of neuronal cell bodies in the subnucleus caudalis of the nucleus tractusspinalis of the trigeminal nerve when the experiment was terminated somewhere between 18 and 30days posttransectionally. Most of degenerating neurons occupied the dorsal half of the subnucleus caudalisipsilateral to the nerve transection. No degeneration observable at the light microscopic levelwas seen in control experiments which examined the effects of either transection or strychnine admin-istration alone. The time-dependency of transsynaptic degeneration, together with the fact that aglycine antagonist enhanced the transsynaptic effect, suggests that the transsynaptic neuronal destructionis caused by the electrical hyperactivity of injured primary neurons.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679659894272
  • NII論文ID
    130004001444
  • DOI
    10.2330/joralbiosci1965.28.69
  • ISSN
    03850137
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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