2-Amino-4-Phenylthiazoleのマゴイに対する麻酔作用に関する電気生理学的研究
書誌事項
- タイトル別名
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- Electrophysiological Surveys on the Anesthetic Properties of 2-Amino-4-Phenylthiazole upon Carp (<I>Cyprinus carpio</I>)
抄録
Surveys were performed regarding the electrophysiological characteristics of inhalation.anesthesia with 2-amino-4-phenylthiazole upon carp (Cyprinus carpio Linnaeus).Major centrifugal nerve-muscle systems (such as spinal nerve with levator muscle of anal or pectoral fin and cerebral nerve with mandibular muscle) and major sensory organs with centripetal nerve systems (such as olfactory organ with its nerve, eye with optic nerve, labyrinth with.the VIII nerve and lateral organs with the X nerve) were observed to be still electrophysiologically active under the anesthetized condition. Any detrimental effect upon heart beating under the anesthetized condition was not observed so far with the electrocardiograms directly derived from the exposed hearts.Any depressive effect on the action potential of an isolated. preparation of postesophageal ample of the alimentary canal was not observed by the direct.application of the compound in Masugi's solution.The electroretinogram under the anesthetized.condition was still normal.The electrical response of optic lobe of midbrain was also still normal under the anesthetized condition when an eye in the opposite side was irradiated by incandescent lamp.Temporary depressive effects observed in the extent of the present investigation were summarized as follows: (1) Although the inhibitory effect on the function of the olfactory system (from olfactory organ to its nerve via olfactory bulb) was not observed, .the electrical response of forebrain seemed to be weakened under anesthetized condition.This was reinforced by the direct application of the compound into forebrain by fine glass capillary. The direct application upon the isolated axon of olfactory nerve did not give the depressive effects. (2) Although the inhibitory effect on the acousticolateral system was not observed, the induced action potentials around the frontal inside of medulla.oblongata (near pons) seemed to be weakened under the anesthetized condition when spinal cord was electrically stimulated.The same depressive effect was observed only by the direct application of the compound into inferior lobe of interbrain with fine glass capillary. (3) Spontaneous 16-18 Hz wave derived from the center part of cerebellum was rapidly disappeared and reappeared in the anesthesia and its recovering process.This was also reinforced by the direct application into cerebellum. (4) Under critical condition at inhalation anesthesia such as in the application of high concentration and/or a long time run, autonomic character-istic of respiratory center seemed to be disordered, and finally a paralysis in the center caused death.The direct application of the compound into deep position of pons caused a seizure type discharge similar to the case of the critical treatment under inhalation anesthesia. Under the anesthesia in an appropriate grade, the oxygen uptake due to respiration was decreased to one fourth of that under vigorous swimming condition and was approximately equal to the oxygen uptake under the stationary condition.The above experimental evidences seemed to imply that the characteristic of inhalation anesthesia caused by 2-amino-4-phenylthiazole upon carp should be attributed to its centrally acting mechanism.
収録刊行物
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- 魚類学雑誌
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魚類学雑誌 18 (3), 128-138, 1971
The Ichthyological Society of Japan
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詳細情報 詳細情報について
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- CRID
- 1390001204768688768
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- NII論文ID
- 130004018504
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- ISSN
- 18847374
- 00215090
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
