New Insights into Therapeutic Strategies for the Treatment of Peritoneal Fibrosis: Learning from Histochemical Analyses of Animal Models

• Kitamura Mineaki

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Nishino Tomoya

  Second Department of Internal Medicine, Nagasaki University School of Medicine

• Obata Yoko

  Second Department of Internal Medicine, Nagasaki University School of Medicine Medical Education Development Center, Nagasaki University Hospital

• Ozono Yoshiyuki

  Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences

• Koji Takehiko

  Department of Histology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences

• Kohno Shigeru

  Second Department of Internal Medicine, Nagasaki University School of Medicine

抄録

Encapsulating peritoneal sclerosis (EPS) is a fatal complication that can occur in patients undergoing long-term peritoneal dialysis. It is characterized by bowel obstruction and marked sclerotic thickening of the peritoneal membrane. Although the mechanisms underlying the development of EPS are complex, angiogenesis, inflammation, and peritoneal fibrosis are known to be essential factors. Now, several animal models that exhibit EPS have pathophysiology similar to that of human EPS and have been proposed for use in research to provide insights into it. Recent histochemical methods also help us to understand the pathophysiology of EPS. Advances in basic research based on the findings in those animal models have enabled the development of several strategies for the prevention and treatment of EPS. We describe here interventional studies in some animal models for peritoneal fibrosis, one of the histological disorders findings characteristic to EPS, and we highlight the need for a sophisticated animal model that closely resembles human conditions.

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 47 (4), 133-143, 2014

  日本組織細胞化学会

キーワード

• peritoneal dialysis
• encapsulating peritoneal sclerosis
• angiogenesis
• inflammation
• peritoneal fibrosis

詳細情報

• CRID: 1390282679837845504
• NII論文ID: 130004053991
• DOI: 10.1267/ahc.14025
• ISSN: 13475800
• ISSN: 00445991
• Web Site: https://www.jstage.jst.go.jp/article/ahc/47/4/47_14025/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015292268
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可