Anti-Obesity Effect and Action Mechanism of Adenophora triphylla Root Ethanol Extract in C57BL/6 Obese Mice Fed a High-Fat Diet
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- LEE Seong-Eun
- Department of Public Health, Keimyung University
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- LEE Eun-Hei
- Department of Public Health, Keimyung University
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- LEE Tae-Jong
- Department of Pathology, Daegu Fatima Hospital
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- KIM Seung-Won
- Department of Public Health, Keimyung University
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- KIM Bae-Hwan
- Department of Public Health, Keimyung University
書誌事項
- タイトル別名
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- Anti-Obesity Effect and Action Mechanism of <i>Adenophora triphylla</i> Root Ethanol Extract in C57BL/6 Obese Mice Fed a High-Fat Diet
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This study investigated the anti-obesity effect of Adenophora triphylla root ethanol extract (ATREE). C57BL/6 mice were divided into five groups, a normal diet group (N), a control group fed only high-fat diet (HFD) (C), a positive control group fed HFD with 0.5% catechin (PC), and groups fed HFD with 0.5% (E1) or 1% (E2) ATREE. The body weight gain, hematological and serum biochemistry data, and anti-oxidative index in the liver and epididymal adipose tissue were improved significantly in the E group (E1, E2), as compared to the C group. As for histological findings, adipocyte size was reduced by ATREE. E group (E1, E2) showed significant increases in adiponectin, AMPK, and PPAR-α, and significant decreases in TNF-α, GPDH, and PPAR-γ, as compared to the C group. The above findings indicate that ATREE might have an anti-obesity effect through antioxidant and anti-inflammatory action. It is considered ATREE can be used as a natural treatment for obesity and metabolic syndrome induced by oxidative stress.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 77 (3), 544-550, 2013
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681456413056
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- NII論文ID
- 10031164773
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3svkt1Chsw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 024389369
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- PubMed
- 23470751
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可