Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

DOI Web Site Web Site PubMed 参考文献11件
  • Park Se Jin
    Department of Life and Nanopharmaceutical Science, Kyung Hee University
  • Ahn Young Je
    Department of Life and Nanopharmaceutical Science, Kyung Hee University
  • Oh Sa Rang
    College of Pharmacy, Keimyung University
  • Lee Younghwan
    Department of Life and Nanopharmaceutical Science, Kyung Hee University
  • Kwon Guyoung
    Department of Life and Nanopharmaceutical Science, Kyung Hee University
  • Woo Hyun
    Department of Life and Nanopharmaceutical Science, Kyung Hee University
  • Lee Hyung Eun
    Department of Life and Nanopharmaceutical Science, Kyung Hee University
  • Jang Dae Sik
    Department of Life and Nanopharmaceutical Science, Kyung Hee University Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
  • Jung Ji Wook
    Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University
  • Ryu Jong Hoon
    Department of Life and Nanopharmaceutical Science, Kyung Hee University Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University

この論文をさがす

抄録

Alzheimer’s disease, a neurodegenerative disorder, is characterized by progressive cognitive impairment associated with the disruption of cholinergic neurotransmission. The aim of the present study was to evaluate the effect of α- or β-amyrin, a type of pentacyclic triterpene, on the cognitive impairment induced by scopolamine, a muscarinic acetylcholine receptor antagonist. To measure the abilities of various types of learning and memory, we conducted step-through passive avoidance task. Scopolamine induced deficits in learning and memory processes in mice, which were antagonized by a single administration of α-amyrin (2 or 4 mg/kg) or β-amyrin (4 mg/kg), respectively. Additionally, in vitro analysis revealed that acetylcholinesterase activity was inhibited by β-amyrin, but not by α-amyrin. Furthermore, Western blot analysis revealed that the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β) were significantly enhanced by a single administration of α- and β-amyrin in the hippocampus. Finally, the memory ameliorating effects of α- or β-amyrin on the scopolamine-induced cognitive impairments were significantly blocked by ERK inhibitor U0126. The present study suggests that α- and β-amyrin may ameliorate the cognitive impairment induced by hypocholinergic neurotransmission via the activation of ERK as well as GSK-3β signaling.

収録刊行物

参考文献 (11)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ