神経除去腎におけるtubulo-glomerular feedback

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  • Tubulo-Glomerular Feedback in the Denervated rat Kidney
  • シンケイ ジョキョ ジン ニ オケル tubulo glomerular fe

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Micropuncture studies were performed in Inactin-anesthetized rats to investigate the mechanism of denervation natriuresis and to determine whether tubulo-glomerular feedback might be modified by renal denervation. Denervation was produced by application of 10% phenol in absolute alcohol to the renal artery and proved to be adequate histochemically using Falck's method. Urinary sodium excretion was higher in the denervated kidney than in the contralateral or in the normal one. Whole kidney and single nephron GFR (SNGFR) remained unchanged after denervation, indicating that denervation natriuresis might be caused by deficits of nervous control of tubular function. As compared to the normal kidney, late proximal ratio of tubular fluid-to-plasma polyfructosan concentration, (TF/P)p, were lower, with no difference in early distal (TF/P)p in denervated ones. Fractional and absolute reabsorption of water in the proximal convolutions were depressed in the denervated rats. It is concluded that renal denervation results in a primary decrease of proximal tubular reabsorption of filtrate. A small effect of denervation on the more distal nephron is not completely ruled out. The proximal SNGFR was greater than the distal SNGFR in the normal, sham-denervated and denervated kidney. The differences between proximal and distal SNGFR were not different among three groups. It is suggested that tubulo-glomerular feedback, which operates in the normal kidney, can elicit the response in the absence of sympathetic innervation.

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