熱性けいれん，てんかん，髄膜炎および非神経疾患におけるせき髄液ｐｒｏｓｔａｇｌａｎｄｉｎ　Ｆ２αの検討　ＩＩ

• 玉井 勇

  埼玉県立小児医療センター準備室

• 武井 忠夫

  国立相模原病院小児科

• 太田 秀臣

  国立相模原病院小児科

• 渡辺 幸彦

  スペシャルレファレンスラボラトリー

• 前川 喜平

  東京慈恵会医科大学小児科

書誌事項

タイトル別名

• Prostaglandin F<SUB>2α</SUB> Concentrations in the Cerebrospinal Fluid of Children with Febrile Convulsions, Epilepsy, Meningitis or Non-Neurological Diseases

抄録

Our previous work has indicated that the levels of prostaglandinF_2α (PGF_2α) in the cerebrospinal fluid (CSF) were increased during febrile convulsions. The purpose of this study was to investigate the relationshipbetween CSF PGF_2α levels and types of epilepsy or febrile convulsions and to analyze the factors affecting the CSF PGF_2α levels.<BR>CSF PGF_2α was measured by radioimmunoassay. Children with febrile convulsions (31 cases), with epilepsy (32 cases), with meningitis (31 cases), and with non-neurological diseases (20 cases) were tested (total 114 cases).<BR>A 4.5-fold increase of CSF PGF_2α levels (239.3±69.0pg/ml [mean±SE], n=22) was seen in simple febrile convulsion cases and a 2.5 fold increase of CSF PGF_2α levels (130.9±36.3, n=9) in complex febrile convulsion cases, as compared to the levels of CSF PGF_2α (53.5±8.7, n=20) in children with non-neurological diseases. The mean CSF PGF_2α levels (43.0±4.6, n=32) in epilepsy cases was not statistically significantly different from that in non-neurological diseases. There was no statistical difference between CSF PGF_2α levels and types of epilepsy.<BR>When the body temperature was normal, the mean CSF PGF_2α levels had no relation with the age. When the body temperature was between 37.5°C and 40°C, the levels in infants were higher than those in older children and adults. The levels in infants with febrile convulsions were significantly higher than those in infants with non-neurological diseases. The CSF PGF_2α levels in children with meningitis were high. The mean CSF PGF2a levels (118.8±19.1, n=11) in bacterial meningitis cases was not statistically different from that in viral menigitis cases (107.1±19.6, n=27).<BR>The CSF PGF_2α levels in meningitis cases were high on admission and gradually decreased after the therapy. The results from our studies revealed that PGF_2α of the central nervous system was markedly increased in infants with febrile convulsions and in children with cerebral inflammatory disorders.

収録刊行物

• 脳と発達

  脳と発達 14 (5), 489-496, 1982

  THE JAPANESE SOCIETY OF CHILD NEUROLOGY

キーワード

• 脊髄液prostaglandin F<SUB>2α</SUB>
• 熱性痙攣
• てんかん
• 髄膜炎

詳細情報

• CRID: 1390001204553830144
• NII論文ID: 130004067873
• DOI: 10.11251/ojjscn1969.14.489
• ISSN: 18847668
• ISSN: 00290831
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可