妊娠初期ラットにおけるｐｒｏｓｔａｇｌａｎｄｉｎ　Ｆ２αおよびＥ２による黄体退縮に及ぼすｌｕｔｅｏｔｒｏｐｉｃ　ｆａｃｔｏｒの効果

• 堀越 順彦

  関西医科大学産科学婦人科学教室

書誌事項

タイトル別名

• The effect of luteotropic factors on luteolysis by prostaglandin F2.ALPHA. and E2 in early pregnant rats.

抄録

There are various causes of abortion in the first trimester. Of all of these, endocrine dysfunction is least understood, and no definite treatment has been established.<BR>Therefore, the effect of luteotropic factors (prolactin, luteinizing hormone-releasing hormone, human chorionic gonadotropin, progesterone, and estradiol) on the breakdown of the endocrine system by the luteolytic factors (prostaglandin F₂α and E₂), was examined in early pregnant rats.<BR>1. Prolactin and luteinizing hormone-releasing hormone showed no luteotropic action for the corpus luteum of normal early pregnant rats. Human chorionic gonadotropin showed no luteotropic action, but follicle stimulating action was observed. Progesterone showed slight luteotropic action. Estradiol showed luteolytic action to induce abortion and can therefore be thought of as a luteolytic factor.<BR>2. It was ascertained that prostaglandin F₂α and E₂ caused luteolysis in early pregnant rats. This resulted in the breakdown of the endocrine system leading to an abortion in early pregnant rats. It was suggested that the prostaglandins acted directly against the corpus luteum. The luteolytic effect of prostaglandin F₂α was higher than that of prostaglandin E₂.<BR>3. Prolactin and luteinizing hormone-releasing hormone could not prevent the breakdown of the endocrine system by prostaglandin F₂α and E₂ in early pregant rats.<BR>Human chorionic gonadotropin showed luteotropic action, and prevented the breakdown of the endocrine system by prostaglandins. Its action was thought to be via its receptor in the corpus luteum graviditatis.<BR>Progesterone has a slight luteotropic action, as it maintained the endocrine system, which maintains pregnancy through secondary action against the luteolysis by prostaglandins. [Adv Obster Gynecol 47(1) : 61-76, 1995 (H7.1)]

収録刊行物

• 産婦人科の進歩

  産婦人科の進歩 47 (1), 61-76, 1995

  近畿産科婦人科学会

キーワード

• abortion
• prostaglandins
• luteolysis
• luteotropic factors

詳細情報

• CRID: 1390282679924221952
• NII論文ID: 130004069577
• DOI: 10.11437/sanpunosinpo1949.47.61
• ISSN: 13476742
• ISSN: 03708446
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可