The Protease as a Cleansing Agent and Its Stabilization by Chemical Modification.

• Masunaga Takuji

  KOSÉ Corporation, Research Laboratory

• Yasukohchi Tohru

  Oleo Chemical Research Laboratory, NOF Corporation

• Hirobe Midori

  KOSÉ Corporation, Research Laboratory

• Arakane Kumi

  KOSÉ Corporation, Research Laboratory

• Adachi Katsura

  KOSÉ Corporation, Research Laboratory

抄録

The effect of protease as a cleansing agent and the improvement of protease stability by chemical modification with polyethylene glycol derivatives were studied. The proteolytic actions of Bioprase and papain on keratins and sweat proteins, which are major proteinic impurities on the skin, were compared. Bioprase degraded both more effectively than papain. Although Bioprase possesses potential usefulness as a cosmetic material, it has a defect: low staility in a system containing water. This defect prevents the application of Bioprase to various preparations except for powder-type preparations. To improve the stability of the native Bioprase, it was chemically modified with copolymers of α-allyl-ω-methoxy polyoxyethylene and maleic anhydride. The stability of Bioprase was extremely improved by the modification. The modified Bioprase was further stabilized by adding such polyols as 1, 3-butylene glycol, glycerin, and propylene glycol. Some nonionic surfactants did not decrease the stability of the modified Bioprase. This method for stabilization allows the application of enzyme to various preparations. By continual use of a cleansing preparation containing the modified Bioprase, skin conditions improved.

収録刊行物

• 日本化粧品技術者会誌

  日本化粧品技術者会誌 27 (3), 276-288, 1993

  日本化粧品技術者会

詳細情報

• CRID: 1390282679477833856
• NII論文ID: 130004069718
• DOI: 10.5107/sccj.27.276
• ISSN: 18844146
• ISSN: 03875253
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可