ラジカル捕捉天然素材の探索

DOI

書誌事項

タイトル別名
  • Investigation of Natural Free-Radical Scavengers.

抄録

Active oxygen and free radicals have been implicated to cause various skin problems including wrincle, maculae and inflammation. In this study, we focused on squalene, and first investigated the effects of squalene peroxide, regard as being formed by the action of active oxygen and free radicals on the skin, in hairless mice. We observed various disorders including thickening of the epidermis and progressive cornification.<br>To investigate means of protection from oxidative disorders caused by active oxygen and free radicals, we focused next on plants which can grow even under situations where active oxygen and free radicals can easily be formed. We searched for natural materials of plant origin which can effectivity scavenge various active oxygen and free radicals. As a results, several plants showing high radical-scavenging activity were selected. Their radical-scavenging activities were further improved through limit the period of plant gathering, use of fresh leaves, selection of scavenging ability through breeding and combination of different plant extracts.<br>The experimental creams preparation containing certain combinations of extracts effectively prevented peroxidization of sebum by sunlight on human skin in situ. They also protected against squalene peroxidization induced by sunlight of titanium oxide commonly used in foundations.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390001204500911104
  • NII論文ID
    130004069809
  • DOI
    10.5107/sccj.32.292
  • ISSN
    18844146
    03875253
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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