書誌事項
- タイトル別名
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- STABIHTY OF CEFTEZOLE AGAINST VARIOUS β-LACTAMASES FROM GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA
- Ceftezole ノ カクシュ ベータ Lactamase ニ タイスル ア
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A newly devised cephalosporin-derivative, ceftezole (CTZ), was investigated for its stability to various β-lactamases.<BR>Though about 60% of clinically isolated, ampicillin resistant E. coil and Klebsiella spp. were found to produce penicillinase type β-lactamase mediated by conjugative R plasmids, CTZ was still highly effective against them because of its nonhydrolysable character by such types of β-lactamase.<BR>On the other hand, some strains of Ent. cloacae, Serratia marcescens and Pr. vulgaris were highly resistant not only to penicillins but also cephalosporin derivatives including CTZ. Ent. cloacae Nek-39, one of the resistant strains, was confirmed to produce both plasmid-mediated penicillinase type and chromosomally originated cephalosporinase type f3-lactamases, by means of Sephadex G-75, CM-cellulose and DEAE-cellulose column chromatography. CTZ was tolerant to the former g-lactamase but not to the latter one.<BR>CTZ was not hydrolysed also by penicillinase produced by penicillin G resistant Staph. aureus, and it showed marked antibacterial effect on that.<BR>It may be concluded that CTZ is one of the excellent chemotherapeutics for infectious diseases caused by ampicillin resistant E. coli and Klebsiella, and by penicillin G resistant Staphylococcus as well.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 24 (4), 635-644, 1976
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681258856448
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- NII論文ID
- 130004070979
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- NII書誌ID
- AN00186653
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- ISSN
- 18845894
- 00093165
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- NDL書誌ID
- 1705188
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可