Sultamicillinの眼科領域における検討

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タイトル別名
  • STUDIES ON SULTAMICILLIN IN THE FIELD OF OPTHALMOLOGY
  • ゼンガンブエンセイ シッカン ニ タイスル 1 0パーセント Medryson

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Fundamental and clinical studies on sultamicillin were carried out in the field of ophthalmology, and the following results were obtained.<BR>1. The MICs of sultamicillin against S. aureus isolated from infectious eye disease ranged from ≤0.2-100μg/ml, and against S. epidermidis from ≤0.2-12.5μg/ml, and against K. pneumoniae from 6.25-25μg/ml and against E. cloacae from 12.5-<100μg/ml.<BR>2. High concentration of ABPC in tear and low concentration of ABPC in aqueous humor were detected after oral administration of 50mg/kg sultamicillin in rabbits.<BR>3. Serum concentration of ABPC in rabbits reached a peak at 30 minutes after oral administration of 50mg/kg sultamicillin and the peak serum level was 36.0μg/ml.<BR>4. Sultamicillin was administered to 17 patients with eye infections including 11 cases with hordeolum, 5 cases with mild corneal infection and 1 case with dacryocystitis acuta. The effectiveness rate was 76.4% in all cases. No side effects were observed in all cases.

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