産婦人科領域におけるHBKの点滴静注療法の検討

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  • CLINICAL EVALUATION OF HBK WITH INTRAVENOUS DRIP INFUSION IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

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HBK, a new aminoglycoside antibiotic, was evaluated with the administration method of intravenous drip infusion on tissue penetration and clinical efficacy in obstetrical and gynecological infections, and the following results were obtained.<BR>Concentrations in serum and pelvic organ tissues such as uterus and adnexs were determined following intravenous one hour drip infusion of 75 mg. Penetration of HBK in venous serum and uterine arterial serum found to be good and same with the peak level of 4.81-5.29μg/ml were obtained. The levels in pelvic organ tissues ranged from 0.04 to 3.64μg/g were distributed and its variation were simulated with serum level.<BR>HBK was given to 2 cases of endometritis, 2 cases of post partum intrauterine infection, 1 case of adnexitis with endometritis, 3 cases of pelvic cellulitis and 2 cases of post operative wound infection with a dose of 75 mg one hour drip infusion, 2 times daily and 90% of clinical efficacy on diagnosis, 50% of bacteriological response on diagnosis, 45% of eradication rate on isolated organisms were obtained. No side effect was observed.

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