産婦人科領域におけるHBKの基礎的・臨床的検討
書誌事項
- タイトル別名
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- FUNDAMENTAL AND CLINICAL STUDIES OF HBK IN THE FIELD OF OBSTETRICS AND GYNECOLOGY
抄録
HBK, a new aminoglycoside, was studied fundamentally And clinically in the held of, obstetrics and gynecology.<BR>1) In the study of MICs of HBK, the peak of MIC for S. aureus (100-fold diluted inocula) was 0.39μg/ml, the peak of MICa for E. ioli and S. marcescens were 1.56μg/ml, the peak of MIC for K. pneumoniae was 0.78μg/ml, and the peak of MICa for P. mirabilis, P.vulgaris and P. aeruginosa were 3.13μ/ml. And the peak of MICs for these microbes were comparable to that of DKB.<BR>2) When mothers were injected with 50 mg of HBK intramuscular injection, the maximum level of HBK in the mother's serum was 9.6μg/ml 43 minutes after the injection, and the level in the umbilical cord serum reached a peak of 3.4μg/ml 1 hour 4 minutes after the injection, and the level in the amniotic fluid reached a peak of 0.8μg/ml 2 hours 5 minutes after the injection. The level of HBK in newborn and maternal milk was below the detectable limit in all cases.<BR>3) A total of 12 cases, including each one case of mammary abscess, . mastitis, endometritis, cellulitis, infection of pelvic dead space, pelvic peritonitis and pyelonephritis and 5 cases of acute cystitis, were injected with 50-100mg of HBK by intramuscular injection or intravenous drip twice a day for 2 to 15 consecutive days. The clinical effect was excellent in 5 cases, good in 3 cases, poor in 3 cases and unknown in 1 case. Side effect was not observed in all cases, wh, ile, clinical laboratory data found elevation of S-GOT, S-GPT, Al-P and γ-GTP in 1 case.
収録刊行物
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- CHEMOTHERAPY
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CHEMOTHERAPY 34 (Supplement1), 638-645, 1986
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390282681258064128
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- NII論文ID
- 130004072432
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- ISSN
- 18845894
- 00093165
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可