耳鼻咽喉科領域感染症におけるSY5555の基礎的・臨床的検討

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  • Laboratory and clinical studies on SY5555 in otorhinolaryngological infection

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Pharmacokinetic and clinical studies were carried out on SY5555 in otorhinolaryngological infection.<BR>The results were as follows.<BR>1) Tissue concentrations after 100 mg or 200 mg p.o. in fasting state were N.D. 0.12 μg/g in tonsil, 0.05μg/g in mucous membrane of maxillary sinus, N.D.-0.05 μg/g in nasal polyp and N. D. in mucous membrane of auris media.<BR>2) The drug was clinically evaluated in 35 patients with otitis media, sinusitis, tonsillitis, pharyngitis and otitis externa. Overall clinical efficacy was excellent in 14, good in 12, fair in 7 and poor in 2 cases, The efficacy rate was 74.3%.<BR>3) Gastrointestinal symptoms, such as diarrhea, nausea, were observed in 5 of 39 patients, and a mild increase in platelets was observed as an abnormal laboratory finding in 1 case.

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