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- YOSHIOKA MORIMASA
- The Kitasato Institute
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- KUNII TOYO
- The Kitasato Institute
書誌事項
- タイトル別名
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- I. ACQUIRED IN VITRO RESISTANCE TO PENICILLIN, MITOMYCIN C, TETRACYCLINE AND STREPTOMYCIN
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抄録
1. Type 12, type 14 and unknown type group A streptococci were serially transferred in penicillin (Pc)-, streptomycin (SM)-, tetracycline (TC)-, actinomycin C-, and mitomycin C (MC)-gradient agar.<br>2. Among resistant mutants obtained, the SM and TC resistant mutants retained β-hemolytic activity on blood agar, while all of 3 MC and 2 Pc resistant mutants lost β-hemolysis and showed α-hemolysis.<br>3. The cross resistance between Pc and MC resistance was observed.<br>4. Sugar fermentation of resistant mutants did not differ from that of the parent strains, but mouse virulence decreased.<br>5. Group and type specific antigenicities of α-hemolytic variants were weakened or lost, but no consistent pattern was apparent.<br>6. α-Hemolytic variants lost the ability to produce streptolysin S, streptolysin O, and hyaluronidase productions, and their streptokinase activity was lowered.<br>7. The natural occurrence of antibiotic resistant group A streptococci and the difficulties presented in their isolation from humans is discussed.
収録刊行物
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- Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｉｃｒｏｂｉｏｌｏｇｙ
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Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｍｉｃｒｏｂｉｏｌｏｇｙ 9 (2), 87-99, 1965
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