漢方薬(金鵄丸)によると考えられる薬物性肝障害の1例

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  • A CASE OF DRUG INDUCED LIVER INJURY CAUSED BY KINSHIGAN

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We presented a case of liver injury induced by Kinshigan, oriental herb drug. A 54 year old female took Kinshigan for 8 months before admission. After taking 60 bits of the drug for 7 months, she started to take double dose (120bits) and had severe general malaise and icterus. On admission, total bilirubin, s-GOT and s-GPT were increased markedly. The virus antibodies, the autoantibodies and lymphcyte stimulation test by Kinshigan were all negative. Hapatic encephalopathy did not developed but prothrombin time showed 56.2% at 3rd week after admission. 12 weeks after admission, she recovered from liver dysfunction. Laparoscopy revealed mild liver atrophy and severe hepatic necrosis. Histological findings of biopsy specimen showed multilobular necrosis, degeneration, portal cellular infiltration. In this case, severe acute hepatitis were supposed to be induced by herb drug Kinshigan.

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