ウシ血小板血管透過性因子の循環多形核白血球減少ウサギおよびヒスタミン受容体きっ抗剤被処置ウサギに対する効果

• 干川 就可

  杏林大学医学部病理学第一講座

• 新野 史

  杏林大学医学部病理学第一講座

• 井村 穣二

  杏林大学医学部病理学第一講座

• 芦原 義弘

  杏林大学医学部病理学第一講座

• 白澤 健二朗

  杏林大学医学部病理学第一講座

書誌事項

タイトル別名

• Effects of bovine platelet vascular permeability factor on the polymorphonuclear leukocyte-depleted or antihistamine-pretreated rabbits.

抄録

Effects of bovine platelet α-granule acid extract (BPAE) on vascular permeability were examined in the rabbits subjected to either depletion of polymorphonuclear (PMN) leukocytes by nitrogen mustard (nitrogen mustard-N-oxide hydrochloride, 20-40mg/Kg, i. v.) or pretreatments with histamine antagonists of H₁-(chlorpheniramine maleate, 10mg/Kg, i. p.) and H₂-receptors (cimetidine, 50mg/Kg, i. v.). Increase in vascular permeability due to BPAE (0.1ml of 50 or 250μg/ml) was evaluated by leaked ¹²⁵I-albumin (30μCi, i. v.). and its activity was correlated with fine structures of the reaction. Simultaneously, inflammatory cell infiltration occurred in the vascular wall as early as 3-5 minutes. The vascular permeability activity was gradually increased during the observation periods, 1 minute- 3 hours. On the other hand, effects of BPAE on the vascular permeability in rabbits were strongly inhibited by depletion of PMN leukocytes, but not effectively inhibited by pretreatment with the histamine H₁- and H₂-receptor antagonists.<br>In conclusion, it is confirmed that the vascular permeability factor is present in BPAE as has been described in human platelets. Furthermore, it is suggested that BPAE plays a role in the vascular permeability response as a PMN leukocyte-dependent mediator.

収録刊行物

• 血液と脈管

  血液と脈管 18 (1), 19-25, 1987

  一般社団法人 日本血栓止血学会

キーワード

• bovine platelet vascular permeability factor
• polymorphonuclear leukocyte
• histamine H₁- and H₂-receptor antagonists
• ¹²⁵I bovine serum albumin, nitrogen mustard

詳細情報

• CRID: 1390282679834833536
• NII論文ID: 130004092540
• DOI: 10.2491/jjsth1970.18.19
• ISSN: 18842372
• ISSN: 03869717
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可