Telithromycinの細菌学的検討

• 井上 松久

  北里大学医学部微生物学

• 佐藤 優子

  北里大学医学部微生物学

• 岡本 了一

  北里大学医学部微生物学

書誌事項

タイトル別名

• Bacteriological study of telithromycin
• Antibacterial activities against clinical isolates and the resistance inducibility
• 臨床分離株に対する抗菌力と耐性誘導能

抄録

In vitro antibacterial activity of telithromycin (TEL), a novel ketolide antibiotic, was examined in comparison with erythromycin A (EM), clarithromycin (CAM), rokitamycin (RKM), ampicillin (ABPC), cefpodoxime (CPDX), levofloxacin (LVFX) and teicoplanin (TEIC). The ability of TEL to induce macrolide resistance was also studied in comparison with EM, CAM and RKM. TEL showed a broad antibacterial spectrum and potent antibacterial activity against clinically isolated gram-positive cocci. TEL also exhibited excellent antibacterial activities comparable to existing macrolides against Haemophilus influenzae and Moraxella catarrhalis, gram-negative bacteria. Almost all strains of clinically isolated inducible macrolide-resistant Staphylococcus aureus and Streptococcus pneumoniae were highly susceptible to TEL. Various concentration of TEL did not induce EM resistance in S. aureus.

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 51 (Supplement1), 46-54, 2003

  公益社団法人 日本化学療法学会

キーワード

• <I>in vitro</I>抗菌力
• 臨床分離株
• 耐性誘導能

詳細情報

• CRID: 1390001206290429312
• NII論文ID: 130004102677
• DOI: 10.11250/chemotherapy1995.51.supplement1_46
• ISSN: 18845886
• ISSN: 13407007
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可