メフェナム酸とデンプングリコール酸ナトリウムの摩砕混合物の減圧，加温処理による結晶性の低下

• 櫻井 正太郎

  東京女子医科大学病院薬剤部

• 杉原 正泰

  東京女子医科大学病院薬剤部

書誌事項

タイトル別名

• Decrease of Crystallization of Triturated Mixtures of Mefenamic Acid and Sodium Starch Glycolate by Heating at a Reduced Pressure.

抄録

The triturated mixtures of mefenamic acid (MFA) and Explotab ^® (EX) were prepared by means of powder/powder mixing technique.After storage under reduced pressure at 60°C for 5 hr, with scanning electron microscopy, it seemed likely that EX was transformed to a porous powder.The crystal peaks of MFA by X-ray diffraction had almost disappeared.The dissolution profiles of MFA from the triturated mixtures stored under reduced pressure at 60°C for 5 hr were enhanced in comparison with that from a freshly prerared mixture.With the increase of either the storage temperature or the time under reduced pressure, the particle size of MFA tended to increase on the surface of EX, and MFA also tended to peel from the surface of EX.Consequently, the crystallization of MFA was accelerated.

収録刊行物

• 病院薬学

  病院薬学 18 (3), 204-212, 1992

  一般社団法人 日本医療薬学会

キーワード

• mefenamic acid
• Explotab
• reduced pressure
• dissolution profile
• X-ray diffraction
• scanning electron microscopy

詳細情報

• CRID: 1390282679754589696
• NII論文ID: 130004103087
• DOI: 10.5649/jjphcs1975.18.204
• ISSN: 21859477
• ISSN: 03899098
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可