ヒドロキシジン急性薬物中毒患者における血中濃度と中毒症状
書誌事項
- タイトル別名
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- Serum Hydroxyzine Concentrations and Toxic Symptom in Acute Intoxication Patients.
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The serum drug concentrations in 6 cases of acute hydroxyzine intoxication patients were measured by HPLC. The patients were admitted about 1-10 hours after ingesting from 200 to 15000mg hydroxyzine. The serum hydroxyzine levels were within a range of 0.12-1.70μg/mL. The elimination half-lives were within a range of 4.7-111 hours during treating the patients by forced diuresis. The serum hydroxyzine levels associated with drowsiness was>0.51μg/mL, while that associated with vomiting was >0.51μg/mL and that with is miosis was> 1.40μg/mL. Only one fetal case was encountered. However, the fetal case could possibly have been due to trazodone rather than hydroxyzine because the concentration of hydroxyzine was 0.12μg/mL.
収録刊行物
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- 病院薬学
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病院薬学 26 (1), 13-16, 2000
一般社団法人 日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204775633664
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- NII論文ID
- 110001166945
- 130004103203
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- NII書誌ID
- AN00002794
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- ISSN
- 21859477
- 03899098
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可