THE FUNDAMENTAL AND CLINICAL STUDIES ON MINOCYCLINE DRY-SYRUP IN INFECTIONS IN OTORHINOLARYNGOLOGIC FIELD

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  • 耳鼻咽喉科領域感染症に対するMinocycline Syrup剤の基礎的, 臨床的検討
  • ジビ インコウカ リョウイキ カンセンショウ ニ タイスル Minocycline Syrupザイ ノ キソテキ リンショウテキ ケントウ

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Abstract

Minocycline is a new tetracycline family antibiotic which has a broad antibacterial spectrum, and is more potent than other tetracyclines. Minocycline was tested with the following results:<BR>1.In vitro antibacterial activity: The minimum inhibitory concentration of minocycline was estimated by an agar-plate dilution method. Minocycline inhibited the growth of 60 strains of coagulase-positive Staphylococcus aureus at <0.19-50mcg/ml. Minocycline sensitivity is higher than other tetracyclines.<BR>2. Serum level: A peak serum level of 2.3mcg/ml was reached 2 hours after oral administration of 100mg minocycline dry-syrup in healthy children, followed by a gradual decrease in the level. An effective level of 0.9mcg/ml was still demonstrable after 24 hours.<BR>3. Concentration in tissues: Two hours after the oral administration of 100mg minocycline drysyrup, 1.5mcg/g was found in a human platine tonsilla specimen, and 0.9mcg/g in a human maxillary sinusitis specimen, while 2.2 mcg/ml in serum.<BR>4. Clinical effect: By the oral administration of 4mg/kg minocyclne dry-syrup, 27 of 30 cases (90%) of infections in otorhinolaryngological field showed good results. No side effect was observed.

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