ONO-1078 (プランルカスト水和物) の通年性鼻アレルギーに対する臨床評価

DOI
  • 奥田 稔
    Japan Asthma and Al1ergy Clinic
  • 海野 徳二
    Dapartment of Otorhinolaryngology, Asahikawa Medical College
  • 和田 哲治
    Dapartment of Otorhinolaryngology, Asahikawa Medical College
  • 犬山 征夫
    Department of Otorhinolaryngology, School of Medicine, Hokkaido Universjty
  • 間口 四郎
    Department of Otorhinolaryngology, School of Medicine, Hokkaido Universjty
  • 形浦 昭克
    Department of Otorhinolaryngology, Sapporo Medical University
  • 朝倉 光司
    Department of Otorhinolaryngology, Sapporo Medical University
  • 寺田 修久
    Department of Otorhinolaryngo1ogy, Senbokukumiai General Hospital
  • 高坂 知節
    Department of Otorhinolaryngology, Tohoku University, School of Medicine
  • 稲村 直樹
    Department of Otorhinolaryngology, Tohoku University, School of Medicine
  • 中林 成一郎
    Department of Otorhinolaryngology, Tohoku University, School of Medicine
  • 戸川 清
    Department of Otorhinolaryngology, School of Medicine, Akita University
  • 岡本 美孝
    Department of Otorhinolaryngology, School of Medicine, Akita University
  • 松崎 全成
    Department of Otorhinolaryngology, School of Medicine, Akita University
  • 中野 雄一
    Department of Otorhinolaryngology, Niigata University, School of Medicine
  • 中村 英生
    Department of Otorhinolaryngology, Niigata University, School of Medicine
  • 田口 喜一郎
    Department of Otorhinolaryngology, Shinshu University, School of Medicine
  • 石山 哲也
    Department of Otorhinolaryngology, Shinshu University, School of Medicine
  • 村上 嘉彦
    Department of Otorhinolaryngology, Yamanashi Medical University
  • 久松 建一
    Department of Otorhinolaryngology, Yamanashi Medical University
  • 亀井 民雄
    Department of Otorhinolaryngology, Gunma University, School of Medicine
  • 室井 昌彦
    Department of Otorhinolaryngology, Gunma University, School of Medicine
  • 今野 昭義
    Department of Otorhinolaryngology, School of Medicine, Chiba University
  • 山越 隆行
    Department of Otorhinolaryngology, School of Medicine, Chiba University Department of Otorhinolaryngology, Chosei General Hospital
  • 八木 聰明
    Department of Otorhinolaryngology, Nippon Medical School
  • 大久保 公裕
    Department of Otorhinolaryngology, Nippon Medical School
  • 滝沢 竜太
    Department of Otorhinolaryngology, Nippon Medical School
  • 野村 恭也
    Department of Otorhinolaryngology, Showa University, School of Medicine
  • 吉見 健二郎
    Department of Otorhinolaryngology, Showa University, School of Medicine
  • 藤谷 哲
    Department of Otorhinolaryngology, Showa University, School of Medicine
  • 冨田 寛
    Department of Otorhinolaryngology, Nihon University, School of Medicine
  • 山田 久美子
    Department of Otorhinolaryngology, Nihon University, School of Medicine
  • 山内 由紀
    Department of Otorhinolaryngology, Nihon University, School of Medicine
  • 渡辺 健一
    Department of Otorhinolaryngology, Nihon University, School of Medicine
  • 臼井 信郎
    II Department of Otorhinolaryngology, Toho University, School of Medicine
  • 湯浅 貴文
    II Department of Otorhinolaryngology, Toho University, School of Medicine
  • 渡辺 光弘
    II Department of Otorhinolaryngology, Toho University, School of Medicine
  • 飯塚 啓介
    Department of Otorhinolaryngology, Japanese Red Cross Society, Medical Center
  • 市川 朝也
    Department of Otorhinolaryngology, Japanese Red Cross Society, Medical Center
  • 矢島 洋
    Department of Otorhinolaryngology, Shizuoka Saiseikai Hospital
  • 後藤 裕一
    Department of Otorhinolaryngology, Shizuoka Saiseikai Hospital
  • 野末 道彦
    Department of Otorhinolaryngology, Hamamatsu University, School of Medicine
  • 向高 洋幸
    Department of Otorhinolaryngology, Hamamatsu University, School of Medicine
  • 宇佐神 篤
    Department of Otorhinolaryngology, Hamamatsu Medical Center
  • 柳田 則之
    Department of Otorhinolaryngology, Schoolof Medicine, Nagoya University
  • 久野 佳也夫
    Department of Otorhinolaryngology, Schoolof Medicine, Nagoya University
  • 馬場 駿吉
    Department of Otorhinolaryngology, Medical school, Nagoya City University
  • 高木 一平
    Department of Otorhinolaryngology, Medical school, Nagoya City University
  • 北尾 俊二
    Department of Otorhinolaryngology, Medical school, Nagoya City University
  • 岩田 重信
    Department of Otorhinolaryngology, Fuj ita Health University, School of Medicine
  • 内藤 健晴
    Department of Otorhinolaryngology, Fuj ita Health University, School of Medicine
  • 井畑 克朗
    Department of Otorhinolaryngology, Fuj ita Health University, School of Medicine
  • 横山 尚樹
    Department of Otorhinolaryngology, Fuj ita Health University, School of Medicine
  • 坂倉 康夫
    Department of Otorhinolaryngology, Faculty of Medicine, Mie University
  • 鵜飼 幸太郎
    Department of Otorhinolaryngology, Faculty of Medicine, Mie University
  • 増田 佐和子
    Department of Otorhinolaryngology, Faculty of Medicine, Mie University
  • 渡邊 行雄
    Department of Otorhinolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • 中川 肇
    Department of Otorhinolaryngology, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • 古川 仭
    Department of Otorhinolaryngology, Schoolof Medicine, Kanazawa University
  • 作本 真
    Department of Otorhinolaryngology, Schoolof Medicine, Kanazawa University
  • 齋藤 等
    Department of Otorhinolaryngology, Fukui Medical School
  • 森 繁人
    Department of Otorhinolaryngology, Fukui Medical School
  • 村上 泰
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
  • 竹中 洋
    Department of Otorhinolaryngology, Kyoto Prefectural University of Medicine
  • 荻野 敏
    Department of Otorhinolaryngology, Osaka University, Medical school
  • 仙波 治
    Department of Otorhinolaryngology, Osaka Kohseinenkin Hospital
  • 山下 敏夫
    Department of Otorhinolaryngology, Kansai Medical University
  • 久保 伸夫
    Department of Otorhinolaryngology, Kansai Medical University
  • 池田 浩己
    Department of Otorhinolaryngology, Kansai Medical University
  • 入船 盛弘
    Department of Otorhinolaryngology, Osaka Prefectural Habikino Hospital
  • 白石 孝之
    Department of Otorhinolaryngology, Sakai Municipal Hospital
  • 馬場 謙治
    Department of Otorhinolaryngology, Sakai Municipal Hospital
  • 中上 哲広
    Department of Otorhinolaryngology, Sakai Municipal Hospital
  • 松永 喬
    Department of Otorhino1aryngology, Nara Medical University
  • 矢形 礼貴
    Department of Otorhino1aryngology, Nara Medical University
  • 成尾 一彦
    Department of Otorhino1aryngology, Nara Medical University
  • 榎本 雅夫
    Department of Otorhinolaryngology, Japanese Red Cross Society, Wakayama Medical Center
  • 芝埜 彰
    Department of Otorhinolaryngology, Japanese Red Cross Society, Wakayama Medical Center
  • 生駒 尚秋
    Department of Otorhinolaryngology, Tottori University, School of Medicine
  • 鈴木 健男
    Department of Otorhinolaryngology, Tottori University, School of Medicine
  • 小宮山 荘太郎
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
  • 竹田 和夫
    Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University
  • 石川 哮
    Department of Otorhinolaryngology, School of Medicine, Kumafnoto University
  • 鮫島 靖浩
    Department of Otorhinolaryngology, School of Medicine, Kumafnoto University
  • 緒方 憲久
    Department of Otorhinolaryngology, School of Medicine, Kumafnoto University
  • 森満 保
    Department of Otorhinolaryngology, Miyazaki Medical College
  • 松浦 宏司
    Department of Otorhinolaryngology, Miyazaki Medical College
  • 堀之内 謙一
    Department of Otorhinolaryngology, Miyazaki Medical College
  • 大山 勝
    Department of Otorhinolaryngology, Faculty of Medicine, Kagoshima University
  • 島 哲也
    Department of Otorhinolaryngology, Faculty of Medicine, Kagoshima University
  • 中島 光好
    Department of Pharmacology, Hamamatsu University, School of Medicine

書誌事項

タイトル別名
  • Clinical study of leukotriene antagonist ONO-1078 (pranlukast hydrate), on perennial allergic rhinitis
  • A double-blind, dose finding study (late phase II study)
  • 3用量比較による多施設共同二重盲検比較試験 (用量設定試験)

抄録

通年性鼻アレルギーに対するONO-1078 (プランルカスト水和物) の有効性, 安全性および至適用量を検討するために, プランルカストの3用量を用いた多施設共同による二重盲検比較試験法を実施した.<BR>総症例数は, プランルカスト75mg/日群 (L群) 66例, 225mg/日群 (M群) 68例, 450mg /日群 (H群) 64例の計198例であつた.<BR>最終全般改善度はL群44.8%, M群46.7%, H群64.3%であり, 3群間に用量依存性が認められ, H群がL群に比し有意に高い改善を示した. 鼻アレルギー日記の集計では, L群, M群, H群ともにくしゃみ, 鼻みず (鼻漏), 鼻づまり (鼻閉) の三主徴が経時的に, かつ有意な減少を示し, 鼻みず, 鼻づまりではH群がL群に比較し有意に優れていた. 概括安全度は, 「安全である」でL群93.8%, M群86.6%, H群88.5%, 副作用発現頻度でL群4.6%, M群13.4%, H群11.5%と3群間に用量依存性を認めなかつた. 有用度はL群44.1%, M群45.9%, H群59.6%であり, 用量依存性を認めた.

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詳細情報 詳細情報について

  • CRID
    1390282680474900992
  • NII論文ID
    130004133435
  • DOI
    10.11334/jibi1954.43.5_631
  • ISSN
    04477227
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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