A New Method for Differentiating Benign and Malignant Pleomorphic Clustered Calcifications in Mammography
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- Kikuchi Mari
- Department of Radiology, St. Luke's International Hospital Department of Radiology, Nippon Medical School Musashi Kosugi Hospital
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- Tsunoda Hiroko
- Department of Radiology, St. Luke's International Hospital
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- Kaneshiro Tadashi
- Center for Minimally Invasive Treatment, Nippon Medical School Musashi Kosugi Hospital
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- Takahashi Osamu
- Department of General Internal Medicine, St. Luke's International Hospital
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- Suzuki Koyu
- Department of Pathology, St. Luke's International Hospital
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- Yamauchi Hideko
- Department of Breast Surgery, St. Luke's International Hospital
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- Ichikawa Taro
- Department of Radiology, Nippon Medical School Musashi Kosugi Hospital
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- Kumita Shin-ichiro
- Department of Radiology, Nippon Medical School Hospital
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Objective: Retrospective study to determine whether new mammography imaging characteristics can improve identification of an isolated cluster of coarse heterogeneous and fine pleomorphic calcifications as benign or malignant.<br> Materials and Methods: Institutional review board approval and informed consent were obtained. The study included 123 women (mean age, 50 years: age range, 34-79 years), in whom mammograms had found pleomorphic clustered calcifications, but without abnormal ultrasound findings and who underwent stereotactically-guided vaccum-assisted breast biopsy. Pleomorphic clustered calcifications were classified on the basis of 5 characteristics density, heterogeneity of density, number, heterogeneity of size, and distribution area size (DAS) of calcifications in the mediolateral oblique view (multiplication of the greatest length by the width of the total zone of clustered calcifications in mm2), and correlated with pathological findings.<br> Results: The chi-square test showed significant differences in whether a calcification was malignant or benign only in terms of DAS of calcification (p 0.009). There were significant differences in the association with malignancy of a DAS of 32- to 55 mm2 (p=0.023, odds ratio=4.22), and the association more likely with a DAS of 56 mm2 or larger (p=0.01, odds ratio=5.55) than with a DAS smaller than 18 mm2 as a reference.<br> Conclusion: The DAS is a new and reliable variable for differentiating between benign and malignant pleomorphic clustered calcifications. The DAS improves diagnostic accuracy and is useful for determining whether to proceed with biopsies.<br>
収録刊行物
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- 日医大誌
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日医大誌 81 (2), 70-77, 2014
日本医科大学医学会