Anti-allodynic and Neuroprotective Effects of Koumine, a Benth Alkaloid, in a Rat Model of Diabetic Neuropathy
-
- Ling Qian
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
-
- Liu Ming
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
-
- Wu Min-Xia
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
-
- Xu Ying
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
-
- Yang Jian
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
-
- Huang Hui-Hui
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
-
- Yu Chang-Xi
- Department of Pharmacology, College of Pharmacy, Fujian Medical University
この論文をさがす
抄録
Diabetic neuropathy is characterized by progressive degeneration of nerve fibers associated with diabetes mellitus. Antidepressants and anticonvulsants are the mainstay of pharmacological treatment, but are often limited in effectiveness against the core clinical feature of pain. In the current study, we examined the potential effects of koumine, a Gelsemium elegans BENTH alkaloid, using a rat model of diabetic neuropathy. Rats were administered intraperitoneally a single dose of streptozocin (60 mg/kg) to induce type 1 diabetes. Koumine was given at a dose range of 0.056–7 mg/kg subcutaneously for one week starting 3 weeks after streptozocin adminstration. Behavioral responses to mechanical stimuli were evaluated every day after streptozocin injection. At 4 weeks after streptozocin injection, sensory nerve conduction velocity (SNCV) and morphological alternation of sciatic nerves were assessed by electron microscopy. Diabetic rats developed mechanical hyperalgesia within 3 weeks after streptozocin injection and exhibited reduced SNCV and impaired myelin/axonal structure. Koumine treatment of diabetic rats decreased neuropathic pain behavior as early as after the first administration. At a dose of 7 mg/kg, koumine was more effective than gabapentin (100 mg/kg), and decreased mechanical sensitivity threshold to a level comparable to healthy control. Repeated treatment of koumine significantly reduced the damage to axon and myelin sheath of the sciatic nerve and increased SNCV, without affecting body weight and blood glucose. These findings encourage the use of koumine in the treatment of diabetic neuropathy.
収録刊行物
-
- Biological & Pharmaceutical Bulletin
-
Biological & Pharmaceutical Bulletin 37 (5), 858-864, 2014
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679609164032
-
- NII論文ID
- 130004147326
-
- NII書誌ID
- AA10885497
-
- COI
- 1:STN:280:DC%2BC2cnpsVCktw%3D%3D
-
- ISSN
- 13475215
- 09186158
-
- NDL書誌ID
- 025419994
-
- PubMed
- 24790009
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可