書誌事項
- タイトル別名
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- Effect of 1α-Hydroxycholecalciferol on Hypocalcemia and Renal Function of Chronic Renal Failure
- マンセイ ジンフゼン カンジャ ノ テイ カルシウム ケッショウ ト ジン キ
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The present study was carried out to evaluate the effect of 1α-hydroxycholecalcif erol (1α-(OH)-D3) on serum free and total calcium, parathyroid hormone, alkaline phosphatase, bone X-P change and renal function in 21 hypocalcemic patients under hemodialysis and 7 non-dialysed patients. 1) 21 hypocalcemic patients under hemodialysis were treated with 1α-(OH)-D3 for 6 months. 1α-(OH)-D3 induced a significant increase in serum calcium concentration after 4 weeks and it reached to normal level after 8 weeks. It also induced a significant reduction of raised serum parathyroid hormone and alkaline phosphatase activity after 16 weeks. No significant changes were obtained in phosphate, creatinine and bone X-P. 2) 7 hypocalcemic non-dialysed patients were also treated by 1α-(OH)-D3 for 4 to 20 weeks against 9 normocalcemic chronic renal failure (control). 1α-(OH)-D3 induced a significant increase in serum calcium and reduction of parathyroid hormone after 16 weeks, It also induced a increase in serum creatinine concentration after 12 weeks which was greater than that of control patients. This result suggests that 1α-(OH)-D3 treatment is noxious to the renal function of chronic renal failure.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 23 (1), 13-25, 1981
社団法人 日本腎臓学会
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詳細情報 詳細情報について
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- CRID
- 1390001204859238656
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- NII論文ID
- 130004168659
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- NII書誌ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- NDL書誌ID
- 2342695
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- PubMed
- 7289202
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可