Electron Microscopic and Immunohistochemical Observation of the Mesangial Deposition in Smoldering Glomerulonephitis
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- Murohashi Takeshi
- Departmet of Internal medicine, Nagaoka Red cross Hospital
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- Suzuki Kensuke
- Departmet of Internal medicine, Nagaoka Red cross Hospital
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- Kurokawa Izumi
- Departmet of Internal medicine, Nagaoka Red cross Hospital
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- Takahashi Soichiro
- Departmet of Internal medicine, Nagaoka Red cross Hospital
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- Arai Okuhiro
- Departmet of Internal medicine, Nagaoka Red cross Hospital
Bibliographic Information
- Other Title
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- Smolderig formじん炎を中心としたメサンギウム沈着物の観察
- Smolderig form ジンエン オ チュウシン ト シタ メサンギウム
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Abstract
Renal biopsy specimens obtained from thirty patients who had chance proteinuria and hematuria in spite of normal renal function who observed by electron microscope. Their morphological changes were so-called smoldering glomerulonephritis classified by Kinoshita. In 23 patients the electron high dense deposits were present in the mesangial matrix. In several cases the histological changes were hardly defined as abnormel. IgA deposition in the mesangum was observed in 14 Patients among 15 patients with positive immunof luorescent findings. We tried to mesure the maximum diameter of the largest mesangial deposit and compered it to the width of the basament membrane. These was no particular relationship between the size of the maximum mesangial deposit and the severity of the glomerular lesions. The electron microscopical immunoperoxidase method was done in one patient, ant it was clarified the IgG was localized within the electron high dense deposits in the mesangium. The most striking feature that IgG was observed in the intercellular space between the mesamgial cells. This fact displayed the specific Junctional pathway from the glomerular capillary luman to the paramesangial area and suggested that immune complex was accumulated into the paramesangial area through its way.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 23 (3), 265-276, 1981
Japanese Society of Nephrology
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Keywords
Details 詳細情報について
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- CRID
- 1390282679835857536
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- NII Article ID
- 130004168702
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- NII Book ID
- AN10131749
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- ISSN
- 18840728
- 03852385
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- NDL BIB ID
- 2346935
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- PubMed
- 7311115
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed