書誌事項
- タイトル別名
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- Studies on hemorheology as causative factors of tissue hypoxia in renal failure
抄録
In the present study, we determined erythrocyte 2, 3-diphosphoglycerate (2, 3-DPG), hemoglobin Al (HbAl), oxygen dissociation curve (ODC), erythrocyte defor-mability, erythrocyte osmotic fragility and blood viscosity, using washed erythrocytes for the purpose of investigating causative factors of tissue hypoxia in patients with renal failure. Erythrocyte 2, 3-D and HbAI levels in uremic subjects, regardless of hemodial-ysis, were higher than those in normal subjects. The ODC for erythrocytes showed a right shift in uremic patients before heodial-ysis treatment. However, the ODC in patients with renal failure showed a left shift after hemodialysis. A decreased erythrocyte deformability and an erythrocyte osmotic fragility shifted to the yperosotic side were observed in uremic patients. Moreover, blood viscosity in non-hemodialysis uremic subjects was high at the shear rate of 334sec-1 as compared with that in normal subjects. The above data suggest that these factors are important in developing tissue hypoxia in the treatment of hemodialysis of uremic patients.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 25 (4), 415-419, 1983
社団法人 日本腎臓学会