書誌事項
- タイトル別名
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- A case of Nephrotic Syndrome associated with acquired syphilis
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抄録
A 40-year-old man was admitted to our hospital because of pretibial edema. Physical examination showed generalized edema and rashes on the trunk and the perineum. The pharynx was slightly reddened and the tonsils were enlarged. The relevant laboratory findings were summarized as belows. Urinalysis showed 4+ test for protein with one or two red blood cells, five or six white blood cells, two or three hyaline casts and four or six epithelial cells per highpower field and with one granulated cast per two or three high-power fields. The total serum protein was 3.3 g per 100m1. No Β-haemolytic streptococci were present in the throat culture. Serum antistreptolysin o titer was under 20 dils. Serum complements were not decreased. The ANA test was negative. Serologic tests for syphilis were strongly positive. Renal biopsy showed mild mesangial cell proliferation in the glomeruli and round cell infiltrations of the interstitial tissues on light microscopy. A few small adhesions of the capillary loops to the parietal layers of Bowmann's capsules were also seen. Immunofluorescent study demonstrated a coarse granular deposits of IgG and faint granular deposits of C3 in the capillary loops. The histological diagnosis was membranous glomerulonephritis. The dermatologist diagnosed the rashes on the trunk and the perineum as the secondary syphilitic rash. The final diagnosis was the nephrotic syndrome due to syphilis. He was treated with penicillin. Proteinuria was rapidly decreased. The titers of serum TPHA and STS were also markedly reduced. The nephrotic syndrome disappeared completely. So far as we know, there has been few reports in Japan on the nephrotic syndrome due to syphilis.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 26 (1), 131-137, 1984
社団法人 日本腎臓学会