Evaluation of circulating immune complexes in lupus nephritis by solid phase C1q and conglutinin binding assays.
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- YOSHIDA HARUYOSHI
- The Third Division, Department of Internal Medicine
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- MUSO ERI
- The Third Division, Department of Internal Medicine
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- INOUE SHUJI
- The Department of Pathology, Faculty of Medicine, Kyoto University
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- FURUKAWA FUKUMI
- The Department of Pathology, Faculty of Medicine, Kyoto University
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- SEKITA KEN-ICHI
- The Department of Pathology, Faculty of Medicine, Kyoto University
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- KAWAI CHUICHI
- The Third Division, Department of Internal Medicine
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- HAMASHIMA YOSHIHIRO
- The Department of Pathology, Faculty of Medicine, Kyoto University
抄録
The clinical significance of two assays for circulating immune complexes (CIC), solid phase C1q binding assay (SPC1gBA) and solid phase conglutinin binding assay (SPKgBA), were evaluated in terms of the correlation with anti-DNA antibodies, complement levels, general disease activity, and grades of proteinuria in 63 SLE patients. No significant quantitative correlation was observed between the two tests for CIC, although the positivities of the two were correlated with each other (P<0.025). The presence of SPC1q-CIC as well as anti-dsDNA antibodies showed a clear association with the general disease activity (P<0.001). The amount of SPC1q-CIC was correlated with decreased serum C4 levels (P<0.001), antissDNA (P<0.001) and anti-dsDNA (P<0.005) antibodies, and the grades of proteinuria (P<0.05). On the other hand, SPKg-CIC revealed weak correlations only with the general disease activity and anti-DNA antibodies, and showed no significant correlation with the serum C3 and C4 or grades of proteinuria. These data suggest that compared to SPKgBA, SPC1gBA may represent a more useful diagnostic tool which indicates the general disease activity and reflects the development of nephritis.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 26 (3), 293-300, 1984
社団法人 日本腎臓学会