書誌事項
- タイトル別名
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- Acute renal failure due to rhabdomyolysis. Clinical investi gation on our 6 cases.
- -Clinical investigation on our 6 cases-
- ―自験6例の臨床的検討―
抄録
Six cases of acute renal failure (ARF) due to rhabdomyolysis were experienced be tween 1984 and 1989. Patients' ages ranged from 33 to 92 years old (average ages 61) and all were male. The causes of rhabdomyolysis were as follows : one crush syndrome, one acute arterial occlusion, one diabetic hyperosmolar nonketotic coma and three cases of malignat syndrome due to neuroleptica (mainly haloperidol). Underlying diseases included, one case of abdominal aneurysm, two cases of diabetes mellitus, two cases of schizophrenia and one case of reactive psychosis. Dehydration was considered as an important factor in the onset of rhabdomyolysis and ARF, because it was observed in 4 of the cases in this study. In all cases, the serum levels of potassium, phosphorus and uric acid as well as myoglobin and myogenic enzymes increased markedly. In patients with myoglobinuric ARF, severse metabolic acidosis and hypocalcemia in the oligulic phase and hypercalcemia in the diuretic phase were prominant. Muscle biopsy showed myolytic degeneration in 2 of 4 cases. Five cases were treated with hemodialysis and one case was managed conservatively. All 6 cases had relatively good prognosis. However, 3 cases with malignant syndrome showed outcomes more severe than in the other 3 cases without such syndrome.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 34 (3), 317-324, 1992
社団法人 日本腎臓学会