Changes of Adrenocortical Function and the Ovarian Contribution with Age

• SAITO Hiroshi

  <I>Department of Obstetrics and Gynecology, Showa University School of Medicine</I>

• AKAMATSU Tatsuya

  <I>Department of Obstetrics and Gynecology, Showa University School of Medicine</I>

• YANAIHARA Takumi

  <I>Department of Obstetrics and Gynecology, Showa University School of Medicine</I>

抄録

Dissociation of adrenal cortisol and androgen secretion occurs in elderly men and women. The postmenopausal ovary produces androgens; however, previous reports regarding adrenocortical function in postmenopausal women did not exclude the ovarian contribution to peripheral steroid levels. In the present study, changes in the ovarian contribution to adrenocortical function with age were determined by measuring peripheral concentrations of C₁₉ and C₂₁ steroids before and 2 weeks after ovariectomy. The rapid adrenocorticotropic hormone (ACTH) stimulation test (tetracosactide acetate, 0.25 mg i.v.) was performed, and the age-related difference in the response of steroid levels to ACTH stimulation was also determined in ovariectomized reproductive-age (mean age, 33.0 years, n=6) and postmenopausal women (mean age, 63.3 years, n=9) . After ovariectomy, the concentrations of pregnenolone, 17a-hydroxypregnenolone, progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone, and androstenedione in reproductive-age women decreased significantly to the levels in postmenopausal women. On the other hand, no significant changes in steroid levels before and after ovariectomy were observed in postmenopausal women. When changes in steroid levels in response to ACTH were compared, significant age-related reductions of dehydroepiandro-sterone, and androstenedione were observed with age but Δ4 and Δ5 C₂₁ steroid levels in response to ACTH were preserved. These results suggest that C_17-20 lyase activity decreases but 17a-hydroxylase is maintained for preservation of cortisol in response to ACTH. It is known that P450c17 is a single enzyme that catalyzes activity of both 17α-hydroxylase and C_17-20 lyase. Therefore, changes in adrenal C_17-20 lyase activity with age might affect adrenal androgen production.

収録刊行物

• Ｔｈｅ　Ｓｈｏｗａ　Ｕｎｉｖｅｒｓｉｔｙ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｓｈｏｗａ　Ｕｎｉｖｅｒｓｉｔｙ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅｓ 7 (2), 207-213, 1995

  昭和大学学士会

キーワード

• adrenal cortex
• aging
• ovariectomy
• 17α-hydroxylase
• C<SUB>17-20</SUB> lyase

詳細情報

• CRID: 1390282679350770944
• NII論文ID: 130004190305
• DOI: 10.15369/sujms1989.7.207
• COI: 1:CAS:528:DyaK28XjtVCktbo%3D
• ISSN: 21850968
• ISSN: 09156380
• Web Site: https://www.jstage.jst.go.jp/article/sujms1989/7/2/7_2_207/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可