コリスチンメタンスルホン酸ナトリウムのラットにおける生殖試験　ＩＩＩ　　周産期および授乳期投与試験

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タイトル別名
  • REPRODUCTION STUDIES OF SODIUM COLISTIN METHANESULFONATE. III
  • Sodium colistin methanesulfonate ノ ラット
  • 周産期および授乳期投与試験

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Perinatal and postnatal study of sodium colistin methanesulfonate (CLM) was performed with Wistar strain rats. The dams were given CLM intravenously at doses of 6.25mg, 12.5mg and 25mg/kg from dary 17 of gestation to the 21st day post partum.<BR>Results were given as follows;<BR>1. CLM did not affect general condition, maternal body weight and food consumption in the dams.<BR>2. There was no significant difference between the CLM treated groups and the control group in duration of pregnancy, number of newborns, number of liveborns, number of stillborns, sex ratio and weight of liveborns at delivery. Moreover, no external malformations of liveborns were observed in any treated group.<BR>3. CLM did not affect delivery rate or nursing rate.<BR>4. CLM did not affect postnatal growth, development and differentiation in newborn rats.<BR>5. CLM did not affect postnatal behavior, sensational reflex, spontaneous activity, nerve-muscle ability, learning ability, emotional pattern and reproductive ability in newborn rats.<BR>It can be concluded that CLM does not influence the health of dams and postnatal development of their offspring. In this study, the maximum non-effect dose of CLM was 25 mg/kg in rats.

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