STUDIES ON AC-1370 IN THE FIELD OF OPHTHALMOLOGY

DOI

Bibliographic Information

Other Title
  • AC-1370の眼科領域における検討

Abstract

Fundamental and clinical studies on AC-1370, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained.<BR>1. The MIC of AC-1370 against Staphylococcus aureus isolated from infectious eye diseases ranged from 12.5-100μg/ml, and MIC of AC-1370 against Klebsiella pneumoniae ranged from 1.56-50μg/ml.<BR>2. Aqueous humor concentration of AC-1370 reached maximum (2.6μg/ml) at 1 hour after an i.v. administration of 50mg/kg in rabbits, and the maximum serum concentration (21.0μg/ml) was obtained at 30 minutes after the injection.<BR>3. High concentration in tear and low concentration in aqueous humor were measured after i.v. administration of 50mg/kg AC-1370 in rabbits.<BR>4. Aqueous humor concentration of AC-1370 in rabbits reached peak at 11 hour after subconjunctival injection 10mg/0.1ml and the peak aqueous humor level was 10.1μg/ml.<BR>5. Two patients with ocular suppurative diseases were successfully treated at a daily dose of 1, 000, 2, 000mg AC-1370. 6, No side effect were observed.

Journal

  • CHEMOTHERAPY

    CHEMOTHERAPY 32 (Supplement9), 827-830, 1984

    Japanese Society of Chemotherapy

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