STUDIES ON AC-1370 IN THE FIELD OF OPHTHALMOLOGY
-
- HATANO HIROSHI
- Department of Ophthalmology, Iwaki Municipal Joban Hospital
-
- BABA YASUHIKO
- Department of Ophthalmology, Iwaki Municipal Joban Hospital
-
- ONISHI HITOMI
- Department of Ophthalmology, Iwaki Municipal Joban Hospital
Bibliographic Information
- Other Title
-
- AC-1370の眼科領域における検討
Abstract
Fundamental and clinical studies on AC-1370, a new antibiotic, were carried out in the field of ophthalmology and the following results were obtained.<BR>1. The MIC of AC-1370 against Staphylococcus aureus isolated from infectious eye diseases ranged from 12.5-100μg/ml, and MIC of AC-1370 against Klebsiella pneumoniae ranged from 1.56-50μg/ml.<BR>2. Aqueous humor concentration of AC-1370 reached maximum (2.6μg/ml) at 1 hour after an i.v. administration of 50mg/kg in rabbits, and the maximum serum concentration (21.0μg/ml) was obtained at 30 minutes after the injection.<BR>3. High concentration in tear and low concentration in aqueous humor were measured after i.v. administration of 50mg/kg AC-1370 in rabbits.<BR>4. Aqueous humor concentration of AC-1370 in rabbits reached peak at 11 hour after subconjunctival injection 10mg/0.1ml and the peak aqueous humor level was 10.1μg/ml.<BR>5. Two patients with ocular suppurative diseases were successfully treated at a daily dose of 1, 000, 2, 000mg AC-1370. 6, No side effect were observed.
Journal
-
- CHEMOTHERAPY
-
CHEMOTHERAPY 32 (Supplement9), 827-830, 1984
Japanese Society of Chemotherapy
- Tweet
Details 詳細情報について
-
- CRID
- 1390001206280640384
-
- NII Article ID
- 130004194829
-
- ISSN
- 18845894
- 00093165
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed