淋菌性尿道炎, 淋菌性子宮頸管炎に対するAzthreonamの細菌学的・臨床的検討

• 斎藤 功他

  東京共済病院泌尿器科

書誌事項

タイトル別名

• BACTERIAL AND CLINICAL STUDY ON AZTHREONAM IN GONORRHEA

抄録

The purpose of this study was to determine the susceptibility of N. gonorrhoeae to Azthreonam (AZT). The MIC of AZT against 64 strains of N. gonorrhoeae was examined, and all strains showed MIC of 5 0.78μg/ml, including 7 β-lactamase producing strains.<BR>The effect of treatment with AZT was compared in 86 patients with uncomplicated gonorrhea.<BR>A single-dose regimen of 1.0g AZT i. m., a two-dose regimen of 1.0g and 1.0g, and a three-dose regimen of 1.0g, 1.0g and 1.0 g (one day apart) were given. Three group regimens were equally effective with an overall cure rate of 100%. In patients harbouring β-lactamase producing gonococci the infection was cured.<BR>During the follow-up (7 days after treatment) of 48 patients postgonococcal urethritis (PGU) was diagnosed in 13 (27.1%) patients. Seven (77.8%) out of 9 patients with Chlamydia trachomatis positive cultures who were followed up developed PGU, while only 6 (15.4%) of 39 patients with Chlamydia trachomatis negative culture developed PGU. No subjective side effects were observed.

収録刊行物

• ＣＨＥＭＯＴＨＥＲＡＰＹ

  ＣＨＥＭＯＴＨＥＲＡＰＹ 33 (Supplement1), 713-718, 1985

  公益社団法人 日本化学療法学会

詳細情報

• CRID: 1390001206281057536
• NII論文ID: 130004194973
• DOI: 10.11250/chemotherapy1953.33.supplement1_713
• ISSN: 18845894
• ISSN: 00093165
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可