Imipenem/Cilastatin sodium (MK-0787/MK-0791) の眼科領域における検討

• 葉田野 博

  いわき市立常磐病院眼科

• 若松 和代

  いわき市立常磐病院中央検査室細菌

書誌事項

タイトル別名

• STUDIES ON IMIPENEM/CILASTATIN SODIUM IN THE FIELD OF OPHTHALMOLOGY

抄録

Fundamental and clinical studies on imipenem/cilastatin sodium (MK-0787/MK-0791), a new antibiotics, were carried out in the field of ophthalmology and the following results were obtained.<BR>1. The MIC of MK-0787 against S. aureus and S. epidermidis from infectious eye disease ranged from 0.39 μg/ml-≤0.2 μg/ml, and MIC of MK-0787 against E. cloacae ranged from 0.78 μg/ml-≤0.2 μg/ml.<BR>2. Aqueous humor concentration of MK-0787 reached maximum (2.1μg/ml) and tear concentration reached maximum (1. 9 μg/ml) at 30 minutes after an i. v. administration, 50 mg/50mg/kg of MK-0787/MK-0791 in rabbits, and the maximum serum concentration (20.0 μg/ml) was obtained at 30 minutes after the injection.<BR>3. 4 patients with lid-phlegmone 2 cases, acute dacryocystitis 1 case and infectious corneal ulcer 1 case were successfully treated at a daily dose 250mg of MK-0787/MK-0791.<BR>4. No adverse effects were observed.

収録刊行物

• ＣＨＥＭＯＴＨＥＲＡＰＹ

  ＣＨＥＭＯＴＨＥＲＡＰＹ 33 (Supplement4), 1118-1121, 1985

  公益社団法人 日本化学療法学会

詳細情報

• CRID: 1390001206281496832
• NII論文ID: 130004195045
• DOI: 10.11250/chemotherapy1953.33.supplement4_1118
• ISSN: 18845894
• ISSN: 00093165
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可