Comparative study of carumonam and cefoperazone in complicated urinary tract infections.

• KAWADA YUKIMICHI

  Department of Urology, Fukui Medical School

Bibliographic Information

Other Title

• 複雑性尿路感染症に対するＣａｒｕｍｏｎａｍとＣｅｆｏｐｅｒａｚｏｎｅの比較検討

Abstract

A double blind comparison of carumonam, a new parenteral monobactam antibiotic, and cefoperazone was carried out in the treatment of complicated urinary tract infections due to gram-negative bacilli. Patients received 1g of either carumonam or cefoperasone twice a day for 5 days by intravenous drip infusion.<BR>All patients had pyuria of at least 5 WBCs per high power field, gram-negative bacilluria of at least 10⁴ bacilli per ml of urine and identifiable underlying urinary tract disease. The overall clinical efficacy of the treatment was evaluated by the criteria proposed by the UTI Committee in Japan as excellent, moderate or poor based on the combination of changes in pyuria and bacteriuria.<BR>Of the 213 patients evaluated for the clinical efficacy, 113 patients received carumonam and 100 received cefoperazone. No significant difference in background charecteristics was observed between the two treatment groups. Excellent and moderate responses were obtained in 70.8% of the patient. receiving carumonam and in 61.0% of the patients receiving cefoperazone. This difference was not statistically significant. The overall bacteriological eradication rates obtained were 90.3% of 175 strains in the carumonam group and 80.1% of 151 strains in the cefoperazone group. This difference was statistically significant (P<0.05). Significantly higher eradication rate for S. marcescens was achieved in the carumonam group (P<0.05).<BR>Clinical adverse reactions were observed in two patients (1.1%) in the carumonam group and in one patient (0.6%) in the cefoperasone group. The incidences of patients with elevated S-GOT and S-GPT were significantly lower in the carumonam group (P<0.05).<BR>From the results obtained in this study, we concluded that carumonam was as useful as cefoperasone in the treatment of complicated urinary tract infections due to gram-negative bacilli.

Journal

• CHEMOTHERAPY

  CHEMOTHERAPY 35 (6), 494-519, 1987

  Japanese Society of Chemotherapy

Details

• CRID: 1390001206279381120
• NII Article ID: 130004195613
• DOI: 10.11250/chemotherapy1953.35.494
• ISSN: 18845894
• ISSN: 00093165
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed