眼科領域におけるCefdinirの基礎的・臨床的検討

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  • BASIC AND CLINICAL STUDIES ON CEFDINIR IN OPHTHALMOLOGY

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Cefdinir (CFDN), a new oral cephem, is a broad-spectrum antibiotic similar to cefaclor and amoxicillin with potent antibacterial activity against both Gram-positive and- negative bacteria.<BR>The MIC distribution against Staphylococcus aureus isolated clinically from ocular patients was ≤0.2 to<100μg/ml with a peak value of 0.39μg/ml.<BR>Concentrations of CFDN in aqueous humor and ocular tissue were determined after oral administration of 50mg/kg to rabbits.<BR>CFDN peaked at 1.39μg/ml in aqueous humor 2 h after administration with a ratio of 13.8% to the serum level. Levels of CFDN in external and internal ocular tissues were 0.39-3.52μg/g and 0.41-1.97μg/g or ml 2 h after administration, respectively, but no activity greater than 0.19μg/ml was found in the lens and vitreous body. The CFDN levels in human tarsal gland tissues were 0.37-0.77μg/g at 4 h after a single dose of 200mg.<BR>In the clinical study, CFDN was administered orally in a dose of 100 or 200mg t. i. d. to a total of 43 patients: 7 with blepharitis, 11 with hordeolum, 5 with meibomianitis, 4 with chronic dacryocystitis, 6 with keratitis and, 10 with corneal ulcer.<BR>The clinical efficacy was evaluated as excellent in 10 patients, good in 26, fair in 5 and poor in 1. The clinical efficacy rate was 83.7%.<BR>No adverse reactions were observed.

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